Endocrine Abstracts

The oral antidiabetic drug, glibenclamide, stimulates the insulin producing β-cells constantly through a harsh mechanism which eventually may permanently reverse its endocrinofunction. The study investigates the protective effects from Swietenia seed and endocarp aqueous-methanol extract on pancreatic islets histology in rats of type 2 DM model. Phytochemical analyses were performed prior to the in vivo study to screen the aqueous-methanolic extract of the combin...

Solvent and process variables were critical to optimize the extractions of potential hypoglycemic compounds within medicinal plants. Hence, the undertaken study was designed to evaluate the hypoglycemic effectiveness exhibited by extraction performed in decoction manner using water as solvent and compares it with an aqueous-methanol solvent extraction. To evaluate the extractions prepared, phytochemical assays and in vivo study in induced-diabetic rats were carried ou...